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Analysis of copy number variation of m (6) A regulators identified METTL3 as a prognostic and immune biomarker in bladder cancer

This article was originally published here Cancer Med. October 20, 2021. doi: 10.1002 / cam4.3981. Online ahead of print. ABSTRACT OBJECTIVE: A growing body of evidence has shown an indispensable role for N6 -methyladenosine (m6 A) in human diseases, but variations in copy number (CNV) of m6 A regulatory gene …

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Ixazomib-based maintenance therapy after bortezomib-based induction in non-transplanted multiple myeloma patients: a field study

This article was originally published here Cancer Med. October 16, 2021. doi: 10.1002 / cam4.4313. Online ahead of print. ABSTRACT BACKGROUND: Maintenance treatment with proteasome inhibitors (PIs) may improve outcomes in patients with multiple myeloma (MM), however, the neurotoxicity and parenteral route of bortezomib limits its long-term use. An efficient, …

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Hyperthermia ablation associated with transarterial chemoembolization versus monotherapy for hepatocellular carcinoma: a systematic review and meta-analysis

This article was originally published here Cancer Med. October 16, 2021. doi: 10.1002 / cam4.4350. Online ahead of print. ABSTRACT BACKGROUND AND OBJECTIVES: Existing evidence has indicated that hyperthermia ablation (HA) and HA combined with transarterial chemoembolization (HATACE) are the optimal alternative to surgical resection for patients with hepatocellular carcinoma …

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The role of primary site surgery in metastatic upper urinary tract urothelial carcinoma and a nomogram for predicting survival in patients with metastatic upper urinary urothelial carcinoma

This article was originally published here Cancer Med. October 14, 2021. doi: 10.1002 / cam4.4327. Online ahead of print. ABSTRACT Metastatic upper urinary tract urothelial carcinoma (mUTUC) is a relatively rare urothelial carcinoma, and little attention has been paid to it. Our study established a nomogram by analyzing prognostic factors …

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Prostate Cancer in Multiethnic Asian Men: Real-World Experience in the Prostate Cancer Study in Malaysia (M-CaP)

This article was originally published here Cancer Med. October 9, 2021. doi: 10.1002 / cam4.4319. Online ahead of print. ABSTRACT Prostate cancer is the third most common cancer in Malaysia with a lifetime risk of 1 in 117 men. Here we launched a longitudinal study of prostate cancer in Malaysia …

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Highly sensitive detection of motor mutations from cytology samples and cfDNA in lung cancer

This article was originally published here Cancer Med. October 7, 2021. doi: 10.1002 / cam4.4330. Online ahead of print. ABSTRACT Background: Bronchoscopy is a minimally invasive procedure for diagnosing lung cancer. It sometimes fails to obtain tissue samples, but easily collects cytological samples. METHODS: We developed a PNA-LNA double PCR …

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Prognostic implication of PD-L1 polymorphisms in radiotherapy-treated non-small cell lung cancer

This article was originally published here Cancer Med. October 6, 2021. doi: 10.1002 / cam4.4329. Online ahead of print. ABSTRACT BACKGROUND: To study the impact of programmed dead ligand 1 (PD-L1) polymorphisms on the prognosis of patients with non-small cell lung cancer (NSCLC) treated with curative radiotherapy. METHODS: Four single …

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Possibility of brigatinib-based treatment, or chemotherapy plus anti-angiogenic therapy after resistance of osimertinib carrying EGFR T790M-cis-C797S mutations in patients with pulmonary adenocarcinoma

Cancer Med. October 6, 2021. doi: 10.1002 / cam4.4336. Online ahead of print. ABSTRACT BACKGROUND: There was no standard treatment for patients who developed resistance to osimertinib mediated by the epidermal growth factor receptor (EGFR) T790M-cis-C797S. The aim of this study was to investigate the association between different therapeutic strategies …

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Trust and Shared Decision Making in People with Multiple Myeloma: A Qualitative Study

This article was originally published here Cancer Med. October 5, 2021. doi: 10.1002 / cam4.4322. Online ahead of print. ABSTRACT Background: Multiple myeloma (MM) is an incurable cancer with complex treatment options. Trusting relationships between patient and clinician are essential to promote effective shared decision-making that aligns best clinical practice …

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MicroRNA-501-3p inhibits proliferation of kidney cancer cells by targeting WTAP

This article was originally published here Cancer Med. September 30, 2021. doi: 10.1002 / cam4.4157. Online ahead of print. ABSTRACT BACKGROUND: New evidence suggests that miR-501-3p plays an important role in the pathogenesis and progression of various carcinomas. However, its role and the underlying mechanisms in renal cell carcinoma (RCC) …

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