Accord – Fry Chef http://frychef.com/ Thu, 25 Nov 2021 15:48:10 +0000 en-US hourly 1 https://wordpress.org/?v=5.8 https://frychef.com/wp-content/uploads/2021/03/frychef-icon-70x70.png Accord – Fry Chef http://frychef.com/ 32 32 Triple negative apocrine carcinoma as a rare cause of breast mass in a Syrian woman: a case report and review of the literature | BMC Women’s Health https://frychef.com/triple-negative-apocrine-carcinoma-as-a-rare-cause-of-breast-mass-in-a-syrian-woman-a-case-report-and-review-of-the-literature-bmc-womens-health/ Thu, 25 Nov 2021 13:03:01 +0000 https://frychef.com/triple-negative-apocrine-carcinoma-as-a-rare-cause-of-breast-mass-in-a-syrian-woman-a-case-report-and-review-of-the-literature-bmc-womens-health/

Although apocrine carcinomas were first described by Krompecher et al. [5], the histological criteria for diagnosing apocrine carcinomas were not defined until Japaze et al. suggested that apocrine differentiation, characterized by the proliferation of large, well-defined cells with abundant eosinophilic granular cytoplasm, large vesicular nuclei with an N / C ratio of 1: 2 or greater, and visible nucleoli, should be detected in more 75% of neoplastic cases. cells [6]. Later, Vranic et al. proposed that in terms of the diagnosis of apocrine carcinomas, the aforementioned features should be detected in more than 90% of neoplastic cells with a distinct steroid hormonal profile defined by negative expression of ER and PR and positive expression of AR as in our case [2]. These strict criteria explain the rarity and difficulty of diagnosing pure apocrine carcinomas which constitute less than 4% of breast cancers, compared to the apocrine differentiation which is present in approximately 30% of benign and malignant breast lesions. [1].

Apocrine carcinoma is similar in clinical presentation to invasive ductal carcinoma. They both have a predominance in women over 40 as in our case, and the presentation varies from asymptomatic to the presence of a palpable mass. [1, 7]. Our patient presented with a painless, palpable mass in her left breast with no skin changes.

Apocrine carcinomas have demonstrated disparities in radiological features. Onoué et al. reported two hypoechoic cysts on ultrasound with papillary projections [8], while Gokalp et al. described two invasive apocrine carcinomas presenting as a solid lesion and a complex cyst, respectively [9]. In a study by Seo et, five ACs presented as heterogeneous solid masses of irregular shape not circumscribed on ultrasound [10]. In our case, ultrasound revealed a well-defined hypoechoic cyst with heterogeneous components. On mammography, most cases of apocrine carcinoma present with microcalcifications. However, Kim et al. reported a case of AC presenting as an oval nodule without microcalcifications [11].

The main differential diagnoses are oncocytic carcinoma and invasive ductal carcinoma. Invasive ductal carcinoma is similar in architectural growth pattern to apocrine carcinomas. However, the cytological characteristics of the apocrine cells are crucial to confirm the diagnosis. Apocrine cells are classified into type A cells which are characterized by abundant granular eosinophilic cytoplasm and type B cells which have abundant foamy cytoplasm with intracytoplasmic lipids. In our case, most of the cells were type A. Differentiating apocrine carcinomas from oncocytic carcinomas is more difficult because they both have large, narrowly defined cells with abundant eosinophilic granular cytoplasm. Therefore, immunohistochemistry is essential. Oncocytic carcinomas could be excluded in our case by the negativity of ER and PR with the positivity of AR and GCDFP-15 [1, 12].

Macroscopic cystic disease fluid protein-15 (GCDFP-15) and androgen receptor (AR) are known to be the hallmarks of apocrine differentiation despite their presence in other breast carcinomas. In addition, the negative expression of ER, PR, BCL2 and GATA3 also defines apocrine differentiation [1, 13]. In our case, we succeeded in confirming the diagnosis based on the positive expression of AR, GCDFP-15 and CK, with negative expression of ER, PR and HER2.

Overexpression of HER2 / new was detected in 54% of cases of apocrine carcinoma in a study by Vranic et al. [2], whereas HER2-negative apocrine carcinoma is defined as TNAC triple-negative apocrine carcinoma, which is a rare distinct subtype of triple-negative breast carcinoma TNBCs, characterized by negative expression of ER, PR and HER2 with expression positive AR [1, 2]. In a large population-based study conducted by Liao et al. out of 19,900 cases of TNBC, apocrine carcinomas were diagnosed in 199 cases (1%) [3]. This highlights an additional particular point in our rare case of triple negative apocrine carcinoma, besides being considered – to our knowledge – the first case report in Syria.

Most HER2 / neu negative apocrine carcinomas or triple negative apocrine carcinomas demonstrated EGFR overexpression and vice versa. Also, Vranic et al. detected polysomy of chromosome 7 in several cases of pure apocrine carcinomas [2]. In a study by Farmer et al., Activation of the AR pathway was detected in apocrine carcinomas [14]. In addition, two studies by Naderi et al. demonstrated interference between AR with the extracellular signal-regulated kinase ERK pathway and GCDFP-15 was actively regulated by the aforementioned pathway [15, 16].

Additionally, in a large genomic sequencing study, Sun et al. demonstrated that PIK3CA was the most predominant mutated gene in triple negative apocrine carcinomas, with p.H1047R representing the most recurrent mutation. Therefore, PIK3CA inhibitors could represent promising treatments for TNACs mutated by PIK3CA. The PTEN gene was also strongly mutated in the aforementioned study, while TP53 mutations were less frequently detected in TNAC cases, unlike in triple-negative non-apocrine breast cancers. [17]. In our case, molecular and genetic studies were not available due to economic restrictions in our country, which increased the challenges of diagnosis. However, through detailed clinical, histological and immunohistochemical correlations, we were able to successfully diagnose and manage the patient.

In a large cohort study conducted by Arciero et al., Triple-negative apocrine carcinomas TNACs had significantly better overall survival compared to invasive triple-negative ductal carcinomas TNBCs. In addition, their study demonstrated that most cases of TNAC were associated with older age, lower T stage, and tumor grade. [4]. Similar results have been demonstrated by Wu et al. in a large SEER-based study and in a small, limited case-control study by Meattini et al. Studies have referred this difference to the overexpression of AR and GCDFP-15 which may be associated with decreased tumor proliferation and, subsequently, better prognosis. [18, 19].

In addition, the expression of AR in apocrine carcinomas could represent a potential target for the treatment of TNAC, although studies concerning the efficacy of antiandrogens are still limited. [20]. A study by Gucalp et al. on bicalutamide in patients with triple-negative AR-positive breast cancer reported a 19% clinical improvement in the phase 2 clinical trial [21]. Other promising approaches include targeting the oncogene phosphatidylinositol 3-kinase (PIK3CA) as well as inhibiting CDK4 / 6 cyclin-dependent kinases which are increased in apocrine carcinomas. [22, 23]. In a study by Lia et al., TNBCs with residual disease had better overall survival after adjusting for conventional chemotherapy, while neoadjuvant chemotherapy improved overall survival in TNBC patients with a complete pathological response. [24]. Therefore, the correct treatment decision is still controversial and further studies are recommended to assess appropriate treatment options. In our case, surgical excision had a crucial role in establishing the correct diagnosis in addition to its importance in the treatment of non-metastatic apocrine carcinoma. In addition, adjuvant chemotherapy with paclitaxel and carboplatin was performed as a first-line treatment in our case of triple negative apocrine carcinoma.

In conclusion, although triple negative apocrine carcinomas are extremely rare neoplasms, they should be considered in the differential diagnosis of breast lesions, and the diagnosis should be based on strict criteria by evaluating the morphological features of apocrine differentiation as well. than immunohistochemical examinations. In our manuscript, we sought to present the first case report of a Syrian woman diagnosed with this rare malignant tumor, with the aim of emphasizing the importance of detailed clinical, histological and immunohistochemical correlations despite all the circumstances in order to assess appropriate care.

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Canadian teenager arrested in $ 36.5 million SIM swap heist https://frychef.com/canadian-teenager-arrested-in-36-5-million-sim-swap-heist/ Sat, 20 Nov 2021 14:00:00 +0000 https://frychef.com/canadian-teenager-arrested-in-36-5-million-sim-swap-heist/

This week saw a wave of hacker-related activity in Iran. On Wednesday, a joint US, UK and Australia advisory said Iranian hackers were targeting critical infrastructure targets. The next day, the US Department of Justice indicted two Iranians for meddling in the 2020 election. Russia and China can usually lead the conversation about foreign hacking threats, but Iran does. is more and more asserted in recent years.

Another country surprisingly active in recent times with its cyber attacks? Belarus! As of 2019, it has been widely accepted that the Ghostwriter hacking and disinformation group was Russia, given both its tactics and its targets. But security firm Mandiant revealed this week that Ghostwriter is in fact an operation with ties to the Belarusian military, focused on interfering with the interests of NATO as well as those of the country’s neighbors.

We also took a look at the best password managers – and yes, you do. Android users may also want to check out a new feature in DuckDuckGo that blocks trackers in apps on your phone. And speaking of blocking things, NordicTrack has made it harder for its customers to access a “God Mode” that allows them to watch whatever they want on the giant screen of their treadmill. They therefore defend themselves by sharing workarounds online.

Finally, take a few minutes out of your day to read this in-depth investigation into how Amazon’s lax data security has let its customers down. It’s full of details you won’t soon forget.

And there’s more ! Each week, we collect all the security news that WIRED hasn’t covered in depth. Click on the titles to read the full stories and stay safe.

In a “kids these days” for the record books, a Canadian teenager was arrested this week for allegedly stealing $ 36.5 million in cryptocurrency from a single American victim. It is the biggest theft of its kind. As with so many youth-related cryptocurrency thefts lately, the apparent method was a so-called SIM swap attack, in which the culprit transfers a target’s phone number to their own device, allowing them to ” intercept SMS-based two-factor authentication codes. . There are ways to protect yourself from a SIM swap, but no guaranteed way to stop them; even Jack Dorsey’s own Twitter account has succumbed to the method. In this case, investigators allege that the teenager used his loot in part to purchase a high-value player tag, which are popular items in the SIM trading community.

Among the many criminal hacking gangs operating in Russia, few have done as much damage over the years as Evil Corp. According to the FBI, the group had raised at least $ 100 million by 2019 by robbing hundreds of banks around the world. Like so many online gangs, they recently adopted malware, apparently targeting the National Rifle Association in a recent attack. This week, a BBC journalist traveled to Moscow and a nearby town in search of Evil Corp members Igor Turashev and Maksim Yakubets.

Over the past weekend, thousands of emails were sent by the FBI warning the recipients had been the victims of a cyber attack. In fact, it was the FBI itself that had been compromised. A hacker compromised the agency’s email system, which means they were able to send fake messages with legitimate FBI headers. Fortunately, their interest, as cybersecurity reporter Brian Krebs put it, was farce rather than outright chaos.

In an incident reminiscent of last year’s Cam4 leak, adult streaming site Stripchat exposed data from 65 million users, 421,000 models and 719,000 chat messages over a three-day period earlier this month. -this. The fault was discovered by a security researcher and appears to have been corrected fairly quickly; It is not clear whether malicious actors accessed the data before Stripchat secured it. However, the stakes for these types of sites are particularly high, for both performers and clients, making any exposure of private information a source of particular concern.


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Analysis of risk factors and characteristics of gene mutations at different metastatic sites of lung cancer https://frychef.com/analysis-of-risk-factors-and-characteristics-of-gene-mutations-at-different-metastatic-sites-of-lung-cancer/ Sat, 20 Nov 2021 06:00:00 +0000 https://frychef.com/analysis-of-risk-factors-and-characteristics-of-gene-mutations-at-different-metastatic-sites-of-lung-cancer/

This article was originally published here

Cancer Med. November 19, 2021. doi: 10.1002 / cam4.4424. Online ahead of print.

ABSTRACT

Risk factors vary in terms of the type of lung cancer metastases and specific metastatic organs. In this study, we retrospectively analyzed clinical risk factors for tumor metastases in lung cancer patients and used second-generation gene sequencing to characterize relevant genetic mutations. Risk factors for different metastatic lung cancer sites in the real world were explored to find genes and risk factors differentially expressed in different metastatic organs, which laid the groundwork for further study on models of metastasis and mechanisms of lung cancer. The clinical risk factors for tumor metastasis in 137 lung cancer patients who attended our service from May 2017 to March 2019 were retrospectively analyzed and grouped according to bone metastases, brain metastases, other distant metastases and the absence of metastasis. One or more factor logistic regression analysis was performed to analyze the effect of neutrophils / lymphocytes / platelets / lymphocytes / lymphocyte / monocyte ratio on platelets (PLT) and bone metastases by combining the values ​​of PLT, l age, type of disease, sex, and smoking history. Based on the presence or absence of bone metastases, distal metastases, and lung cancer PLT values, 39 primary lung cancer tissue samples were taken for 773 gene pools and characterization of gene mutations. Tumor mutation burden, gene copy number instability, microsatellite instability and tumor heterogeneity between different groups were analyzed. Age and PLT level were independent risk factors for bone metastases and distal metastases, but not for brain metastases. The RB1 gene was mutated during bone metastasis, and tumor heterogeneity was less in the high PLT group. PLT values ​​were an independent risk factor for distant metastasis to lung cancer other than to the brain. Age has a significant effect on the formation of bone metastases. The RB1 gene mutation was significantly associated with bone metastases.

PMID:34799997 | DO I:10.1002 / cam4.4424

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Comparison of prognosis between patients undergoing radical nephrectomy versus partial nephrectomy for renal cell carcinoma ≤7 cm T3aN0 / xM0: the survival benefit is biased in favor of partial nephrectomy https://frychef.com/comparison-of-prognosis-between-patients-undergoing-radical-nephrectomy-versus-partial-nephrectomy-for-renal-cell-carcinoma-%e2%89%a47-cm-t3an0-xm0-the-survival-benefit-is-biased-in-favor-of-partia/ Thu, 18 Nov 2021 14:03:07 +0000 https://frychef.com/comparison-of-prognosis-between-patients-undergoing-radical-nephrectomy-versus-partial-nephrectomy-for-renal-cell-carcinoma-%e2%89%a47-cm-t3an0-xm0-the-survival-benefit-is-biased-in-favor-of-partia/

This article was originally published here

Cancer Med. 2021 November 14. doi: 10.1002 / cam4.4412. Online ahead of print.

ABSTRACT

BACKGROUND: There is limited and controversial evidence on the prognosis of partial nephrectomy (PN) compared to radical nephrectomy (RN) in patients with T3aN0 / xM0 renal cell carcinoma (RCC) outclassed compared to clinical T1 RCC. In this study, we sought to assess the difference in prognosis after PN versus RN in patients with ≤7 cm T3aN0 / xM0 RCC.

METHODS: From the surveillance, epidemiology and final results database, a total of 3,196 patients receiving PN / RN treatment for RCC T3aN0 / xM0 ≤ 7 cm with only extrarenal fat extension in 2010-2017 have been identified. A cause-specific Cox model adjusted for treatment-weighted inverse probability (IPTW) with hazard ratio (HR) and 95% confidence interval (CI) was used for overall survival (OS) analyzes. ) and cancer-specific survival (CSS). The sensitivity analysis was based on the matching of the propensity scores of the PN and RN groups and the 2010-2013 dataset.

RESULTS: A total of 872 patients underwent PN compared to 2324 undergoing RN. After IPTW adjustment, there was no significant difference in preoperative baseline characteristics between the PN and RN cohorts. Patients who underwent RN had worse OS (HRAdjusted IPTW , 1.46; 95% CI: 1.16-1.84; p = 0.001) and comparable CSS (HRAdjusted IPTW , 1.03; 95% CI: 0.64-1.66; p = 0.890) than those receiving PN in all cohorts and subgroups with T3a RCC ≤4 cm and perinephric fat extension. Additionally, in patients with 4-7 cm T3a RCC with perinephric fat invasion and all sizes of T3a RCC with sinus / perisinus fat extension, PN led to comparable OS and CSS. Sensitivity analyzes validated these results.

CONCLUSION: PN provides comparable OS and OS or even better OS than RN for patients with RCC ≤ 7 cm T3aN0 / xM0. Although our study has some limitations, our results indicated that PN might be oncologically safe for clinical T1 RCC, and even confirmed a pathological exceedance of post-PN T3a.

PMID:34779154 | DO I:10.1002 / cam4.4412

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Reference models and adjuvant treatment after nephrectomy in high-risk locoregional renal cell carcinoma https://frychef.com/reference-models-and-adjuvant-treatment-after-nephrectomy-in-high-risk-locoregional-renal-cell-carcinoma/ Wed, 10 Nov 2021 14:03:05 +0000 https://frychef.com/reference-models-and-adjuvant-treatment-after-nephrectomy-in-high-risk-locoregional-renal-cell-carcinoma/

This article was originally published here

Cancer Med. November 9, 2021. doi: 10.1002 / cam4.4407. Online ahead of print.

ABSTRACT

Background: It is not clear whether patients with renal cell carcinoma (RCC) are routinely assessed for risk of recurrence after nephrectomy and whether patients at high risk of recurrence are seen by providers who can assess application for adjuvant systemic therapy (AST) and clinical trials.

MATERIALS AND METHODS: We identified all patients with locoregional RCC who underwent nephrectomy via an institutional database within the Duke University Health System between April 1, 2015 and December 31, 2019. Medical records were reviewed. to identify patient characteristics, post-nephrectomy referrals, treatment and follow-up. -up. Patients with tumor stage ≥3 and grade ≥2 of regional lymph node metastasis, or both, were classified as at high risk for recurrence.

RESULTS: Of 618 patients with locoregional CRC who underwent nephrectomy, 136 (22%) were at high risk of recurrence. Of these, 25 patients with high-risk disease (18%) were referred to medical oncology to discuss AST; 23 (92%) of these referrals took place in 2018-2019. One patient received adjuvant sunitinib and two patients participated in adjuvant immunotherapy trials. The decision not to receive AST was mainly made by the oncologist in 10 cases (46%), the patient in 8 (36%), and not recorded in 4 (18%) of the 22 cases, for multiple reasons. Individual surgeons referred high-risk patients for AST discussion at varying frequency, ranging from 0% to 100% in 2019.

CONCLUSIONS: Despite the increasing number of patients with locoregional CRC at high risk of recurrence referred to medical oncologists after nephrectomy, few patients have received AST, including participation in clinical trials. With the increase in AST options and ongoing clinical trials in this space, these findings underscore the need for continued efforts to identify effective AST and refer patients most likely to benefit from it to medical oncologists. ClinicalTrials.gov, NCT04309617.

PMID:34751002 | DO I:10.1002 / cam4.4407

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Benefits of screening and monitoring brain MRIs in patients with metastatic melanoma https://frychef.com/benefits-of-screening-and-monitoring-brain-mris-in-patients-with-metastatic-melanoma/ Sat, 06 Nov 2021 06:00:00 +0000 https://frychef.com/benefits-of-screening-and-monitoring-brain-mris-in-patients-with-metastatic-melanoma/

This article was originally published here

Cancer Med. November 5, 2021. doi: 10.1002 / cam4.4342. Online ahead of print.

ABSTRACT

BACKGROUND: New treatments provide long-term survival for subgroups of patients with melanoma brain metastases. Brain magnetic resonance imaging (MRI) can help in the early detection of brain metastases and inform treatment decisions. This study aimed to determine the impact of MRI screening in patients with metastatic melanoma and follow-up MRI in patients with brain metastases from melanoma.

Methods: This retrospective cohort study included patients diagnosed with metastatic melanoma or melanoma brain metastases between June 2015 and January 2018. The impact of MRI screening was assessed during the first 2 years after the diagnosis of melanoma. metastatic. The impact of follow-up MRI scans was examined during the first year after the diagnosis of brain metastases. The number of MRI scans, examination indications, examination results and changes in treatment strategy were analyzed.

RESULTS: A total of 116 patients had no brain metastases at the time of diagnosis of metastatic melanoma. Twenty-eight of these patients (24%) were subsequently diagnosed with brain metastases. Screening MRI detected brain metastases in 11/28 patients (39%), 8 of whom were asymptomatic at diagnosis. In the 96 patients with melanoma brain metastases, the treatment strategy changed after 75/168 follow-up MRI (45%). In patients treated with immune checkpoint inhibitors, the number of treatment changes after follow-up MRIs was lower when the patients were treated longer.

CONCLUSION (S): Screening MRIs help in the early detection of melanoma brain metastases, and follow-up MRIs inform treatment strategy. In patients with brain metastases responding to immune checkpoint inhibitors, treatment changes were less frequently seen after follow-up MRIs. These findings may inform the development of brain imaging protocols for patients with tumors sensitive to immune checkpoint inhibitors.

PMID:34741440 | DO I:10.1002 / cam4.4342

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Breast cancer screening data detailed by researchers at Virginia Commonwealth University (Engaging Rural Communities In Cancer Prevention and Control Research: Development and Preliminary Insights From a Community-based Research Registry): Diagnostics and Screening – Breast Cancer Screening https://frychef.com/breast-cancer-screening-data-detailed-by-researchers-at-virginia-commonwealth-university-engaging-rural-communities-in-cancer-prevention-and-control-research-development-and-preliminary-insights-fro/ Thu, 04 Nov 2021 22:30:12 +0000 https://frychef.com/breast-cancer-screening-data-detailed-by-researchers-at-virginia-commonwealth-university-engaging-rural-communities-in-cancer-prevention-and-control-research-development-and-preliminary-insights-fro/

2021 NOV 04 (NewsRx) – By a Journalist-Staff News Editor at Daily Insurance News – Investigators publish new report on diagnosis and screening – Screening for breast cancer. According to news from Richmond, Virginia, per NewsRx correspondents, the research said: “To report on the development and preliminary results of a community-based cancer registry, including the community-based approach to recruitment, participant profile and risk factor distribution cancer by race / ethnicity and geography. Best practices in community outreach and engagement were used to recruit a diverse convenience sample of Virginia residents (> = 18 years) who oversampled residents living in rural areas, defined as Rural-Urban Continuum Codes (RUCC) 4-9 and Afro-American (AA) / Black residents.

Financial support for this research came from NIH National Center for the Advancement of Translational Sciences (NCATS).

Our press reporters got a research citation from Commonwealth University of VirginiaSeveral methods of administering the survey included an electronic survey (electronic survey) and an in-person survey conducted by community staff. At the time of this analysis, 595 participants are registered; 73% are rural, 46% are AA / black. AA / Black participants reported similar education but lower income (p <0.01) and health literacy (p <0.01), lower alcohol use (p <0.001), less sedentary behaviors (p = 0.01), but a higher BMI (p <0.05) compared to white participants. Rural residents reported significantly lower household income (p <0.001) and greater Medicaid use (p = 0.01) compared to urban participants. Biennial mammography was reported by 82% of women aged 45 to 74 and colonoscopy by 77% of participants over 50. Tobacco use was reported by 17%; no difference in cancer screening or smoking was identified by geography or race. Conclusion and relevance Community engagement strategies have been successful in recruiting diverse residents in the cancer service area. AA / black participants reported fewer cancer risk behaviors, a similar level of education, but lower income and health literacy than white respondents. Qualified examinations of multi-level factor interactions are needed to understand how individual, community and institutional factors converge to maintain cancer disparities in AA / Black Virginians.

According to the editors, the research concluded: “Additional findings indicate a need for smoking cessation, lung cancer screening, obesity treatment and prevention initiatives.

For more information on this research, see: Get involved Rural communities In Cancer prevention and control research: development and preliminary overviews of a community-based research registry. Cancer medicine, 2021. Cancer medicine can be contacted at: Wiley, 111 River Street, Hoboken 07030-5774, NJ, United States. (Wiley-Blackwell – http://www.wiley.com/; Cancer medicine – http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2045-7634)

Press correspondents report that further information can be obtained from Maria D. Thomson, Commonwealth University of Virginia, School of Medicine, Dept Hlth Behav & Policy, One Capitol Sq, 4TH Floor, Richmond, Virginia 23298, United States. Additional authors of this research include Katherine Y. Tossas, Vanessa B. Sheppard and Charlotte garret.

The direct object identifier (DOI) for this additional information is: https://doi.org/10.1002/cam4.4199. This DOI is a link to an electronic document online that is free or to purchase, and can be your direct source for a journal article and its citation.

(Our reports provide factual information on research and discoveries from around the world.)

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Features of contrast ultrasound for the diagnosis of solid clear cell renal carcinoma ≤4 cm: a meta-analysis https://frychef.com/features-of-contrast-ultrasound-for-the-diagnosis-of-solid-clear-cell-renal-carcinoma-%e2%89%a44-cm-a-meta-analysis/ Wed, 03 Nov 2021 15:02:03 +0000 https://frychef.com/features-of-contrast-ultrasound-for-the-diagnosis-of-solid-clear-cell-renal-carcinoma-%e2%89%a44-cm-a-meta-analysis/

This article was originally published here

Cancer Med. November 1, 2021. doi: 10.1002 / cam4.4365. Online ahead of print.

ABSTRACT

Now, solid kidney tumors ≤ 4 cm are the most common, especially the clear cell renal cell carcinoma (ccRCC) subtype of clinically malignant kidney tumors. However, there are no specific features of the contrast ultrasound (CEUS) recommended by the EFSUMB guidelines to distinguish the essence of kidney tumor with different sizes. Therefore, this meta-analysis aimed to assess the ability of CEUS to diagnose a solid ccRCC (sccRCC) ≤4 cm. We performed extensive searches of the Cochrane Library, Embase, PubMed and Web of Science databases from inception until July 28, 2020, for studies reporting CEUS features of sccRCC ≤4 cm lesions. Additional articles were identified through the Chinese National Knowledge Infrastructure database. Studies were independently selected by two investigators and relevant data was extracted. Discrepancies were resolved by discussion with the lead author. The quality of the studies was assessed using the Quality Assessment of Diagnostic Accuracy Studies-2 tool, and the sensitivity and specificity of each study was determined and plotted as a characteristic curve for the functioning of the receptor. Ten studies were included in this meta-analysis. Hyperimprovement showed moderate sensitivity (67% to 89%) and specificity (42% to 75%) for the diagnosis of sccRCC ≤ 4 cm, rapid contrast agent and heterogeneous enhancement showed high diagnostic capabilities (area under the curve (AUC) 0.74-0.84), but the presence of a pseudocapsule and a fast-acting contrast agent had low diagnostic capacity (AUC <0.70). The combination of hyper-enhancement and iso-enhancement showed high sensitivity (98%) for the diagnosis of sccRCC ≤ 4 cm. Hyperimprovement, rapid contrast agent, and heterogeneous enhancement may be specific features that could help identify an sccRCC ≤ 4 cm, while the presence of a pseudocapsule and rapid contrast agent may have low diagnostic values. The combination of multiple indexes can improve the diagnostic value of ECUS for sccRCC ≤4 cm.

PMID:34725960 | DO I:10.1002 / cam4.4365

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Analysis of copy number variation of m (6) A regulators identified METTL3 as a prognostic and immune biomarker in bladder cancer https://frychef.com/analysis-of-copy-number-variation-of-m-6-a-regulators-identified-mettl3-as-a-prognostic-and-immune-biomarker-in-bladder-cancer/ Wed, 20 Oct 2021 15:03:06 +0000 https://frychef.com/analysis-of-copy-number-variation-of-m-6-a-regulators-identified-mettl3-as-a-prognostic-and-immune-biomarker-in-bladder-cancer/

This article was originally published here

Cancer Med. October 20, 2021. doi: 10.1002 / cam4.3981. Online ahead of print.

ABSTRACT

OBJECTIVE: A growing body of evidence has shown an indispensable role for N6 -methyladenosine (m6 A) in human diseases, but variations in copy number (CNV) of m6 A regulatory gene in bladder cancer (BLCA) remains largely unknown.

METHODS: We studied CNVs on all known m6 Regulatory genes using the Cancer Genome Atlas (TCGA) database. The association between CNV events and clinicopathologic as well as molecular characteristics of BLCA patients was explored. Gene set enrichment analysis (GSEA) was performed to reveal related cellular processes. Association between m6 A regulatory gene and immune infiltrates were analyzed by The Tumor Immune Estimation Resource (TIMER) database.

RESULTS: CNV events of m6 Regulatory genes have been observed frequently in BLCA. CNVs of METTL3, METTL14 and METTL16 were correlated with the molecular characteristics of BLCA patients, including the TP53 mutation. CNVs of METTL3 associated with the overall survival (OS) of BLCA patients. METTL3 was also associated with several cellular cancer-related processes, including mitotic spindle assembly, the G2 / M checkpoint, and the E2F target signaling pathway. In addition, the CNVs of m6 Regulatory genes have been correlated with specific types of immune infiltrates.

CONCLUSIONS: There are significant correlations between m6 A regulatory gene with CNV and clinicopathological features. METTL3 along with CNVs have been associated with immune infiltrates and performed as a prognostic marker in BLCA.

PMID:34668652 | DO I:10.1002 / cam4.3981

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Ixazomib-based maintenance therapy after bortezomib-based induction in non-transplanted multiple myeloma patients: a field study https://frychef.com/ixazomib-based-maintenance-therapy-after-bortezomib-based-induction-in-non-transplanted-multiple-myeloma-patients-a-field-study/ Sat, 16 Oct 2021 15:01:45 +0000 https://frychef.com/ixazomib-based-maintenance-therapy-after-bortezomib-based-induction-in-non-transplanted-multiple-myeloma-patients-a-field-study/

This article was originally published here

Cancer Med. October 16, 2021. doi: 10.1002 / cam4.4313. Online ahead of print.

ABSTRACT

BACKGROUND: Maintenance treatment with proteasome inhibitors (PIs) may improve outcomes in patients with multiple myeloma (MM), however, the neurotoxicity and parenteral route of bortezomib limits its long-term use. An efficient, tolerable and practical PI option is needed.

METHODS: In this real-world, single-center study, we retrospectively analyzed the outcome and safety profile of ixazomib maintenance therapy in patients who reached a plateau with stable disease responses or better after bortezomib-based induction therapy in patients with MM not undergoing transplantation.

RESULTS: Of the 71 patients, 37 cases (52.1%) were newly diagnosed MM (NDMM) and 34 cases (47.9%) were relapsed and / or refractory MM (RRMM). The overall response rate (ORR) was 81.7%, including 34 patients (47.9%) with a very good or better response rate (≥VGPR) after a median of nine cycles (6-14) of treatment induction based on bortezomib. Then, the ORR was transformed to 74.6% including 39 patients of ≥VGPR (54.9%) after a median of six courses (2-25) of maintenance treatment with ixazomib. Of these, 18 patients (25.4%) exhibited in-depth responses. With a median follow-up of 26.5 months, the median progression-free survival (PFS) was 28.4 and 16.5 months from the start of bortezomib and 16.2 and 10.0 months from the start of ixazomib in the NDMM and RRMM groups, respectively. Additionally, responses deepened during the maintenance phase (hazard ratio: 0.270, p = 0.007) and ≥VGPR responses during the induction phase (hazard ratio: 0.218, p <0.001) were confirmed to independently predict longer PFS after multivariate analyzes. Serious adverse events (grade 3/4) were relatively rare. Emerging peripheral neuritis (PN) with bortezomib was significantly relived after transition to ixazomib (p <0.001).

CONCLUSION: This real-world analysis demonstrated that oral ixazomib is a favorable long-term administration option for maintenance with efficacy and feasibility and confirmed the association between deepening of responses with ixazomib and prolonged PFS.

PMID:34655168 | DO I:10.1002 / cam4.4313

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